| SYSNO ASEP | 0025545
|
|---|
| Druh ASEP | J - Článek v odborném periodiku
|
|---|
| Zařazení RIV | J - Článek v odborném periodiku
|
|---|
| Poddruh J | Ostatní články
|
|---|
| Název | Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity
|
|---|
| Překlad názvu | RapGEF geny pxf-1 and rap-1 jsou u Caenorhabditis elegans nezbytné pro epiteliální integritu
|
|---|
| Tvůrce(i) | Pellis-van Berkel, W. (NL)
Verheijen, M. H. G. (NL)
Cuppen, E. (NL)
Asahina, Masako (PAU-O)
de Rooij, J. (NL)
Jansen, G. (NL)
Plasterk, R. H. A. (NL)
Bos, J. L. (NL)
Zwartkruis, F. J. T. (NL)
|
|---|
| Zdroj.dok. | Molecular Biology of the Cell
- ISSN 1059-1524
Roč. 16, č. 1 (2005), s. 106-116
|
|---|
| Poč.str. | 11 s.
|
|---|
| Jazyk dok. | eng - angličtina
|
|---|
| Země vyd. | US - Spojené státy americké
|
|---|
| Klíč. slova | Rap signaling pathway ; epidermis ; Caenorhabditis elegans
|
|---|
| Vědní obor RIV | EB - Genetika a molekulární biologie
|
|---|
| CEP | KJB5022303 GA AV ČR - Akademie věd
|
|---|
| CEZ | AV0Z60220518 - PAU-O, BC-A (2005-2011)
|
|---|
| Anotace | The Rap-pathway has been implicated in various cellular processes but its exact physiological function remains poorly defined. We have shown that the C. elegans homologue of the mammalian guanine nucleotide exchange factors PDZ-GEFs, PXF-1, specifically activates Rap1 and Rap2. Deletion of the catalytic domain from pxf-1 leads to hypodermal defects, resulting in lethality. The cuticle secreted by pxf-1 mutants is disorganized and often not shed properly during molting. Disruption of rap-1 leads to a similar, but less severe phenotype, which is enhanced by the simultaneous removal of rap-2. The results demonstrate that the pxf-1/rap pathway in C. elegans is required for maintenance of epithelial integrity, in which it probably functions in polarized secretion.
|
|---|
| Pracoviště | Parazitologický ústav (do r. 2005)
|
|---|
| Kontakt | Kateřina Homrová,katerina.homrova@paru.cas.cz , Tel.: 387 775 406
|
|---|
| Rok sběru | 2006
|
|---|
