Antibacterial nitric oxide- and singlet oxygen-releasing polystyrene nanoparticles responsive to light and temperature triggers

0487024 - ÚACH 2019 RIV GB eng J - Článek v odborném periodiku
Dolanský, Jiří - Henke, P. - Malá, Z. - Žárská, L. - Kubát, Pavel - Mosinger, Jiří
Antibacterial nitric oxide- and singlet oxygen-releasing polystyrene nanoparticles responsive to light and temperature triggers.
Nanoscale. Roč. 10, č. 5 (2018), s. 2639-2648. ISSN 2040-3364. E-ISSN 2040-3372
Grant CEP: GA ČR(CZ) GA16-15020S
Institucionální podpora: RVO:61388980 ; RVO:61388955
Klíčová slova: nanofiber materials * porphyrin photosensitizers * photophysical properties * reactive oxygen
Obor OECD: Inorganic and nuclear chemistry; Physical chemistry (UFCH-W)
Impakt faktor: 6.970, rok: 2018

Novel therapies to prevent bacterial infections are of utmost importance in biomedical research due to the emergence of multidrug-resistant strains of bacteria. Herein, we report the preparation, characterization and antibacterial evaluation of sulfonated polystyrene nanoparticles simultaneously releasing two antibacterial species, nitric oxide (NO) and singlet oxygen (O-2((1)Delta(g))), upon irradiation with visible light. The nanoparticles were prepared by simple and scalable processes from nanofiber membranes with an encapsulated NO photodonor and/or ionically entangled tetracationic porphyrin/phthalocyanine photosensitizers. The release of NO and O-2((1)Delta(g)) from the polystyrene nanoparticles is controlled by light wavelength and dose, as well as by temperature, which influences the diffusion coefficient and solubility of both species in the polystyrene matrix. The concentrations of NO and O-2((1)Delta(g)) were measured by amperometric and time-resolved spectroscopic techniques and by chemical analysis. Due to the efficient photogeneration of both species at physiological temperature and resultant strong antibacterial action observed on Escherichia coli, the nanoparticles are a promising material for antibacterial applications triggered/modulated by light and temperature.
Trvalý link: http://hdl.handle.net/11104/0282013


Vědecká data: RSC publishing