Nanoscaled porphyrinic metal–organic frameworks: photosensitizer delivery systems for photodynamic therapy

0472473 - ÚACH 2018 RIV GB eng J - Článek v odborném periodiku
Bůžek, Daniel - Zelenka, J. - Ulbrich, P. - Ruml, T. - Křížová, I. - Lang, J. - Kubát, Pavel - Demel, Jan - Kirakci, Kaplan - Lang, Kamil
Nanoscaled porphyrinic metal–organic frameworks: photosensitizer delivery systems for photodynamic therapy.
Journal of Materials Chemistry B. Roč. 5, č. 9 (2017), s. 1815-1821. ISSN 2050-750X. E-ISSN 2050-7518
Grant CEP: GA ČR(CZ) GA16-02098S
Institucionální podpora: RVO:61388980 ; RVO:61388955
Klíčová slova: Cell death * Crystalline materials * Cytotoxicity * Diseases * Nanoparticles
Obor OECD: Inorganic and nuclear chemistry; Physical chemistry (UFCH-W)
Impakt faktor: 4.776, rok: 2017

The photocytotoxic activity of porphyrin-containing materials including metal–organic frameworks (MOFs) has attracted ever increasing interest. We have developed a simple synthesis of hexagonal PCN-222/MOF-545 nanoparticles, which are powerful in inducing reactive oxygen species-mediated apoptosis of cancer cells upon visible light irradiation. The extent of the cytotoxic effect well correlates with the nanoparticle size and structural instability. High phototoxicity of the presented nanoparticles and their deactivation within several hours open up the door to possible applications in cancer therapy.


Trvalý link: http://hdl.handle.net/11104/0269775


Vědecká data: RSC publishing