Počet záznamů: 1
Push-Pull-Allenes: The Influences of Substituents on the Activation of Allenes by Biomimetic Zinc Complexes
- 1.0354000 - ÚOCHB 2011 RIV DE eng J - Článek v odborném periodiku
Jahn, Burkhard O. - Eger, W. A. - Anders, E.
Push-Pull-Allenes: The Influences of Substituents on the Activation of Allenes by Biomimetic Zinc Complexes.
Zeitschrift fur Naturforschung. Section B: a Journal of Chemical Sciences. 65b, č. 3 (2010), s. 425-432. ISSN 0932-0776. E-ISSN 1865-7117
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: allenes * substitution effects * carbonic anhydrase
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
Impakt faktor: 0.816, rok: 2010
The influence of substituents at the alien skeleton on the rate-determining step of the reaction with nucleophiles catalyzed by biomimetic zinc complexes was investigated with quantum chemical (especially DFT) methods. Additional examinations were applied to derivatives of the zinc hydroxide complex modeled in analogy to the catalytic center of carbonic anhydrase. Especially suitable substituents in the allene moiety can lead to a significant lowering of the activation barrier. Further we demonstrate that by the application of this principle of a bioanalogous enhancement of reactivity other nucleophiles instead of the biological substrate can also be reactants in completely closed catalytic reaction cycles.
Trvalý link: http://hdl.handle.net/11104/0193095
Počet záznamů: 1