Počet záznamů: 1
Enhanced levels of mitochondrial enzyme 17β-hydroxysteroid dehydrogenase type 10 in patients with Azheimer disease and multiple sclerosis
- 1.0341047 - ÚFE 2010 RIV GB eng J - Článek v odborném periodiku
Krištofíková, Z. - Bocková, Markéta - Hegnerová, Kateřina - Bartoš, A. - Klaschka, J. - Říčný, J. - Řípová, D. - Homola, Jiří
Enhanced levels of mitochondrial enzyme 17β-hydroxysteroid dehydrogenase type 10 in patients with Azheimer disease and multiple sclerosis.
Molecular BioSystems. Roč. 10, č. 5 (2009), s. 1174-1179. ISSN 1742-206X
Grant CEP: GA MZd NR9322
Výzkumný záměr: CEZ:AV0Z20670512
Klíčová slova: 17beta-HSD 10 * Alzheimer disease * SPR sensor
Kód oboru RIV: JB - Senzory, čidla, měření a regulace
Impakt faktor: 4.015, rok: 2009
This paper describes detection of mitochondrial 17-HSD10 enzyme using a surface plasmon resonance (SPR) biosensor and ELISA method. 17-HSD10 enzyme is involved in pathogenesis of Alzheimer disease (AD) and represents a potential target for AD diagnostics. It was demonstrated that the reported SPR biosensor is capable of detecting 17β-HSD10/Aβs complex in CSF samples and it was revealed the patients with AD exhibited elavated levels of 17β-HSD10/Aβs complex compared to the controls.
Trvalý link: http://hdl.handle.net/11104/0184156
Počet záznamů: 1