Počet záznamů: 1
Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir
- 1.0330753 - ÚOCHB 2010 RIV US eng J - Článek v odborném periodiku
Grantz Šašková, Klára - Kožíšek, Milan - Řezáčová, Pavlína - Brynda, Jiří - Yashina, T. - Kagan, R. M. - Konvalinka, Jan
Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir.
Journal of Virology. Roč. 83, č. 17 (2009), s. 8810-8818. ISSN 0022-538X. E-ISSN 1098-5514
Grant CEP: GA MŠMT 1M0508
GRANT EU: European Commission(XE) 37693 - HIV PI RESISTANCE
Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z50520514
Klíčová slova: HIV-1 protease * darunavir * X-ray structural analysis * protease inhibitor * mutations
Kód oboru RIV: CE - Biochemie
Impakt faktor: 5.150, rok: 2009
In this work we report structural and enzymological analysis of a panel of clinically derived mutant HIV-1 proteases with high levels of phenotypic resistance to darunavir. Recombinant virus phenotypic characterization, enzyme kinetics, and X-ray structural analysis are used to explain darunavir resistance development in HIV-positive patiens.
Trvalý link: http://hdl.handle.net/11104/0176467
Počet záznamů: 1