Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain

Rais, R., Vávra, J., Tichý, T., Dash, R. P., Gadiano, A. J., Tenora, L., Monincová, L., Bařinka, C., Alt, J., Zimmermann, S. C., Slusher, C. E., Wu, Y., Wozniak, K., Majer, P., Tsukamoto, T., Slusher, B. S. Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain. Journal of Medicinal Chemistry. 2017, 60(18), 7799-7809. ISSN 0022-2623. E-ISSN 1520-4804. Dostupné z: doi: 10.1021/acs.jmedchem.7b00825