Stem Cells in Regenerative Medicine

0394729 - ÚEM 2014 RIV JP eng J - Článek v odborném periodiku
Syková, Eva - Forostyak, Serhiy
Stem Cells in Regenerative Medicine.
Laser Therapy. Roč. 22, č. 2 (2013), s. 87-92. ISSN 0898-5901
Grant CEP: GA ČR(CZ) GAP304/11/0189; GA ČR(CZ) GBP304/12/G069
Výzkumný záměr: CEZ:AV0Z50390703
Institucionální podpora: RVO:68378041
Klíčová slova: cell therapy * stem cells * clinical study
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy

A number of cardiovascular, neurological, musculoskeletal and other diseases have a limited capacity for repair and only a modest progress has been made in treatment of brain diseases. The discovery of stem cells has opened new possibilities for the treatment of these maladies, and cell therapy now stands at the cutting-edge of modern regenerative medicine and tissue engineering. Here, we briefly review the main achievements and trends in cell-based therapy, with an emphasis on the main types of stem cells: embryonic, mesenchymal stromal and induced pluripotent cells. We discuss questions regarding the application of stem cells, particularly tumorigenicity, immune rejection and danger of gene manipulation. Currently, only MSC seems to be safe and might be considered to be a leading candidate for human application to treat pathologies that affect the cardiovascular, neurological and musculoskeletal systems.
Trvalý link: http://hdl.handle.net/11104/0224294