Genetically modified dendritic cell-based cancer vaccines

0191269 - UMG-J 20010339 RIV CZ eng J - Článek v odborném periodiku
Bubeník, Jan
Genetically modified dendritic cell-based cancer vaccines.
Folia Biologica. Roč. 47, č. 5 (2001), s. 153-155. ISSN 0015-5500. E-ISSN 0015-5500
Grant CEP: GA MZd NC5526
Klíčová slova: dendritic cells * cancer vaccines
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 0.519, rok: 2001

The capacity to present antigens, activate naive T cells and induce primary cellular immunity make DC attractive vehicles for delivery of therapeutic cancer vaccines. Genetically modified DC vaccines can be prepared by transfection with polynucleotides coding for oncoproteins, immunostimulatory cytokines and/or co-stimulatory molecules, transduction with recombinant viral vectors encoding these molecules and tumour cell-DC fusion. The therapeutic effects of these vaccines .I.in ./I. .I.vitro ./I.and .I.in vivo ./I.are discussed.
Trvalý link: http://hdl.handle.net/11104/0087024