Počet záznamů: 1
Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces
- 1.0366346 - MBÚ 2012 RIV GB eng J - Článek v odborném periodiku
Řezanka, Tomáš - Siřišťová, L. - Schreiberová, O. - Řezanka, M. - Masák, J. - Melzoch, K. - Sigler, Karel
Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces.
Environmental Microbiology. Roč. 13, č. 6 (2011), s. 1577-1589. ISSN 1462-2912. E-ISSN 1462-2920
Grant CEP: GA MŠMT 2B08062
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: PERFORMANCE LIQUID-CHROMATOGRAPHY * AVERMECTIN BIOSYNTHESIS * SELECTIVE PRODUCTION
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 5.843, rok: 2011
A biosynthetic pathway using pivalic acid as a starter unit was found in three bacterial species, Alicyclobacillus acidoterrestris, Rhodococcus erythropolis and Streptomyces avermitilis. When deuterium-labelled pivalic acid was added to A. acidoterrestris and R. erythropolis nutrient media it was incorporated into fatty acids to give rise to tert-butyl fatty acids (t-FAs). In addition, in R. erythropolis, pivalic acid was transformed into two starter units, i.e. isobutyric and 2-methylbutyric acid, which served as precursors of corresponding iso-even FAs and anteiso-FAs. In S. avermitilis the biosynthesis also yielded all three branched FAs; apart from this pathway, both pivalic and 2-methylbutyric acids were incorporated into the antibiotic avermectin
Trvalý link: http://hdl.handle.net/11104/0201387
Počet záznamů: 1