Počet záznamů: 1
Rapid changes in gene expression: DNA determinants of promoter regulation by the
- 1.0360790 - MBÚ 2012 RIV GB eng J - Článek v odborném periodiku
Sojka, Luděk - Kouba, Tomáš - Barvík, I. - Šanderová, Hana - Maderová, Zdeňka - Jonák, Jiří - Krásný, Libor
Rapid changes in gene expression: DNA determinants of promoter regulation by the.
Nucleic Acids Research. Roč. 39, č. 11 (2011), s. 4598-4611. ISSN 0305-1048. E-ISSN 1362-4962
Grant CEP: GA MŠMT 2B06065
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: RIBOSOMAL-RNA TRANSCRIPTION * ILV-LEU OPERON * CHAIN AMINO-ACIDS
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 8.026, rok: 2011
In bacteria, rapid changes in gene expression can be achieved by affecting the activity of RNA polymerase with small molecule effectors during transcription initiation. An important small molecule effector is the initiating nucleoside triphosphate (iNTP). At some promoters, an increasing iNTP concentration stimulates promoter activity, while a decreasing concentration has the opposite effect. Ribosomal RNA (rRNA) promoters from Grampositive Bacillus subtilis are regulated by the concentration of their iNTP. Yet, the sequences of these promoters do not emulate the sequence characteristics of [iNTP]-regulated rRNA promoters of Gram-negative Escherichia coli. Here, we identified the 30-promoter region, corresponding to the transcription bubble, as key for B. subtilis rRNA promoter regulation via the concentration of the iNTP
Trvalý link: http://hdl.handle.net/11104/0198257
Počet záznamů: 1