Počet záznamů: 1
Structure of the motor subunit of type I restriction-modification complex EcoR124I
- 1.0341137 - ÚVGZ 2010 RIV US eng J - Článek v odborném periodiku
Lapkouski, Mikalai … celkem 7 autorů
Structure of the motor subunit of type I restriction-modification complex EcoR124I.
Nature Structural & Molecular Biology. Roč. 1, č. 16 (2009), s. 94-95. ISSN 1545-9993. E-ISSN 1545-9985
Výzkumný záměr: CEZ:AV0Z60870520
Klíčová slova: SWI2/SNF2 ATPASE * DNA * ENDONUCLEASE
Kód oboru RIV: CE - Biochemie
Impakt faktor: 12.273, rok: 2009
Type I restriction-modification enzymes act as conventional adenine methylases on hemimethylated DNAs, but unmethylated recognition targets induce them to translocate thousands of base pairs before cleaving distant sites nonspecifically. The first crystal structure of a type I motor subunit responsible for translocation and cleavage suggests how the pentameric translocating complex is assembled and provides a structural framework for translocation of duplex DNA by RecA-like ATPase motors.
Trvalý link: http://hdl.handle.net/11104/0184216
Počet záznamů: 1