Počet záznamů: 1  

Current understanding on TREM-2 molecular biology and physiopathological functions

  1. 1.
    0586948 - BTÚ 2025 RIV NL eng J - Článek v odborném periodiku
    Bharadwaj, Shiv - Groza, Yaroslava - Mierzwicka, Joanna Maria - Malý, Petr
    Current understanding on TREM-2 molecular biology and physiopathological functions.
    International Immunopharmacology. Roč. 134, JUN 15 2024 (2024), č. článku 112042. ISSN 1567-5769. E-ISSN 1878-1705
    Institucionální podpora: RVO:86652036
    Klíčová slova: myeloid cells 2 * tumor-associated macrophages * nasu-hakola-disease * toll-like receptors * alzheimers-disease * single-cell
    Obor OECD: Pharmacology and pharmacy
    Impakt faktor: 4.8, rok: 2023 ; AIS: 0.926, rok: 2023
    Způsob publikování: Open access
    Web výsledku:
    https://www.sciencedirect.com/science/article/pii/S1567576924005605?via%3DihubDOI: https://doi.org/10.1016/j.intimp.2024.112042

    Triggering receptor expressed on myeloid cells 2 (TREM-2), a glycosylated receptor belonging to the immunoglobin superfamily and especially expressed in the myeloid cell lineage, is frequently explained as a reminiscent receptor for both adaptive and innate immunity regulation. TREM-2 is also acknowledged to influence NK cell differentiation via the PI3K and PLC gamma signaling pathways, as well as the partial activation or direct inhibition of T cells. Additionally, TREM-2 overexpression is substantially linked to cell-specific functions, such as enhanced phagocytosis, reduced toll-like receptor (TLR)-mediated inflammatory cytokine production, increased transcription of anti-inflammatory cytokines, and reshaped T cell function. Whereas TREM-2-deficient cells exhibit diminished phagocytic function and enhanced proinflammatory cytokines production, proceeding to inflammatory injuries and an immunosuppressive environment for disease progression. Despite the growing literature supporting TREM-2+ cells in various diseases, such as neurodegenerative disorders and cancer, substantial facets of TREM-2-mediated signaling remain inadequately understood relevant to pathophysiology conditions. In this direction, herein, we have summarized the current knowledge on TREM-2 biology and cell-specific TREM-2 expression, particularly in the modulation of pivotal TREM-2-dependent functions under physiopathological conditions. Furthermore, molecular regulation and generic biological relevance of TREM-2 are also discussed, which might provide an alternative approach for preventing or reducing TREM-2-associated deformities. At last, we discussed the TREM-2 function in supporting an immunosuppressive cancer environment and as a potential drug target for cancer immunotherapy. Hence, summarized knowledge of TREM-2 might provide a window to overcome challenges in clinically effective therapies for TREM-2-induced diseases in humans.
    Trvalý link: https://hdl.handle.net/11104/0355469
     
Počet záznamů: 1  

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