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Wide-spread brain alterations early after the onset of Crohn’s disease in children in remission—a pilot study
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SYSNO ASEP 0602317 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Wide-spread brain alterations early after the onset of Crohn’s disease in children in remission—a pilot study Tvůrce(i) Filip, P. (CZ)
Vojtíšek, L. (CZ)
Jičínská, A. M. (CZ)
Valenta, Zdeněk (UIVT-O) SAI, ORCID, RID
Horák, O. (CZ)
Hrunka, M. (CZ)
Mangia, S. (US)
Michaeli, S. (US)
Jabandžiev, P. (CZ)Číslo článku 1491770 Zdroj.dok. Frontiers in Neuroscience - ISSN 1662-453X
Roč. 18, 03 December 2024 (2024)Poč.str. 11 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova Crohn’s disease ; diffusion tensor imaging ; neuroinflammation ; brain oedema ; MRI relaxometry Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Clinical neurology CEP EH22_008/0004643 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UIVT-O - RVO:67985807 UT WOS 001378530600001 EID SCOPUS 85212197505 DOI https://doi.org/10.3389/fnins.2024.1491770 Anotace BACKGROUND: The research on possible cerebral involvement in Crohn’s disease (CD) has been largely marginalized and failed to capitalize on recent developments in magnetic resonance imaging (MRI). OBJECTIVE: This cross-sectional pilot study searches for eventual macrostructural and microstructural brain affection in CD in remission and early after the disease onset. METHODS: 14 paediatric CD patients and 14 healthy controls underwent structural, diffusion weighted imaging and quantitative relaxation metrics acquisition, both conventional free precession and adiabatic rotating frame transverse and longitudinal relaxation time constants as markers of myelination, iron content and cellular loss. RESULTS: While no inter-group differences in cortical thickness and relaxation metrics were found, lower mean diffusivity and higher intracellular volume fraction were detected in CD patients over vast cortical regions essential for the regulation of the autonomous nervous system, sensorimotor processing, cognition and behavior, pointing to wide-spread cytotoxic oedema in the absence of demyelination, iron deposition or atrophy. CONCLUSION: Although still requiring further validation in longitudinal projects enrolling larger numbers of subjects, this study provides an indication of wide-spread cortical oedema in CD patients very early after the disease onset and sets possible directions for further research Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2025 Elektronická adresa https://doi.org/10.3389/fnins.2024.1491770
Počet záznamů: 1