Počet záznamů: 1
Self-medication by orang-utans (Pongo pygmaeus) using bioactive properties of Dracaena cantleyi
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SYSNO ASEP 0485747 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Self-medication by orang-utans (Pongo pygmaeus) using bioactive properties of Dracaena cantleyi Tvůrce(i) Morrogh-Bernard, H. (ID)
Foitová, I. (CZ)
Yeen, Z. (ID)
Wilkin, P. (GB)
De Martin, R. (AT)
Rárová, Lucie (UEB-Q) RID, ORCID
Doležal, Karel (UEB-Q) RID, ORCID
Nurcahyo, W. (ID)
Olšanský, M. (CZ)Celkový počet autorů 9 Číslo článku 16653 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 7, NOV 30 (2017)Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova STEROIDAL SAPONINS ; CAPUCHIN MONKEYS ; CHIMPANZEES Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Plant sciences, botany CEP LO1204 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GAP505/11/1163 GA ČR - Grantová agentura ČR Institucionální podpora UEB-Q - RVO:61389030 UT WOS 000416891400055 EID SCOPUS 85037049859 DOI 10.1038/s41598-017-16621-w Anotace Animals self-medicate using a variety of plant and arthropod secondary metabolites by either ingesting them or anointing them to their fur or skin apparently to repel ectoparasites and treat skin diseases. In this respect, much attention has been focused on primates. Direct evidence for self-medication among the great apes has been limited to Africa. Here we document self-medication in the only Asian great ape, orang-utans (Pongo pygmaeus), and for the first time, to our knowledge, the external application of an anti-inflammatory agent in animals. The use of leaf extracts from Dracaena cantleyi by orang-utan has been observed on several occasions, rubbing a foamy mixture of saliva and leaf onto specific parts of the body. Interestingly, the local indigenous human population also use a poultice of these leaves for the relief of body pains. We present pharmacological analyses of the leaf extracts from this species, showing that they inhibit TNFα-induced inflammatory cytokine production (E-selectin, ICAM-1, VCAM-1 and IL-6). This validates the topical anti-inflammatory properties of this plant and provides a possible function for its use by orang-utans. This is the first evidence for the deliberate external application of substances with demonstrated bioactive potential for self-medication in great apes. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2018
Počet záznamů: 1