Počet záznamů: 1
Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study
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SYSNO ASEP 0481221 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study Tvůrce(i) Kořínková, Petra (UEB-Q) ORCID
Bazgier, V. (CZ)
Oklešťková, Jana (UEB-Q) RID, ORCID, SAI
Rárová, L. (CZ)
Strnad, Miroslav (UEB-Q) RID, ORCID
Kvasnica, Miroslav (UEB-Q) RID, ORCIDCelkový počet autorů 6 Zdroj.dok. Steroids. - : Elsevier - ISSN 0039-128X
Roč. 127, NOV (2017), s. 46-55Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Brassinosteroids ; BRI1 receptor kinase ; Cross-metathesis ; Molecular docking ; Organic synthesis ; Plant bioassays Vědní obor RIV CC - Organická chemie Obor OECD Organic chemistry CEP GJ15-08202Y GA ČR - Grantová agentura ČR LO1204 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UEB-Q - RVO:61389030 UT WOS 000413607900007 EID SCOPUS 85028510908 DOI 10.1016/j.steroids.2017.08.010 Anotace A series of phenyl analogues of brassinosteroids was prepared via alkene cross-metathesis using commercially available styrenes and 24-nor-5α-chola-2,22-dien-6-one. All derivatives were successfully docked into the active site of BRI1 using AutoDock Vina. Plant growth promoting activity was measured using the pea inhibition biotest and Arabidopsis root sensitivity assay and then was compared with naturally occuring brassinosteroids. Differences in the production of plant hormone ethylene were also observed in etiolated pea seedlings after treatment with the new and also five known brassinosteroid phenyl analogues. Antiproliferative activity was also studied using normal human fibroblast and human cancer cell lines. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2018
Počet záznamů: 1