Počet záznamů: 1
Alterations in Outer Membrane Permeability Favor Drug-Resistant Phenotype of Klebsiella pneumoniae
- 1.0476610 - ÚEB 2018 RIV US eng J - Článek v odborném periodiku
Pulzová, L. - Navrátilová, Lucie - Comor, L.
Alterations in Outer Membrane Permeability Favor Drug-Resistant Phenotype of Klebsiella pneumoniae.
Microbial Drug Resistance-Mechanisms Epidemiology and Disease. Roč. 23, č. 4 (2017), s. 413-420. ISSN 1076-6294. E-ISSN 1931-8448
Institucionální podpora: RVO:61389030
Klíčová slova: drug resistance * efflux pumps * influx * Klebsiella * porin
Obor OECD: Microbiology
Impakt faktor: 2.344, rok: 2017
The increasing number of infections caused by multidrug-resistant and pandrug-resistant bacteria represents a serious worlwide problem. Drug resistance limits available antimicrobials and can lead to suboptimal treatment of bacterial infections. It can be predicted that resistance to more antimicrobial drugs will be acquired by even more bacteria in the future. Among the distinct resistance strategies, preventing drug entrance to intracellular compartment through modification of membrane permeability (bacterial influx) and active export of compounds to the external environment (bacterial efflux) are of particular importance as they limit the interaction of the drug with its intracellular targets and, consequently, its deleterious effects on the cell. Several current studies have extended our understanding of drug resistance mechanisms associated with altered membrane permeability in gram-negative bacteria. In this study, we propose a summary of resistance mechanisms associated with transport of drugs across bacterial cell envelope exploited by Klebsiella pneumoniae, one of the most common nosocomial infection-causing pathogens. The better understanding of molecular bases of drug transport in/out of the single cell may have consequence for success in antimicrobial therapy of infection caused by drug-resistant Klebsiella.
Trvalý link: http://hdl.handle.net/11104/0273077
Název souboru Staženo Velikost Komentář Verze Přístup 2017_Pulzova_MICROBIAL DRUG RESISTANCE_413.pdf 2 229.1 KB Jiná povolen
Počet záznamů: 1