Synthesis and antiproliferative activities of novel O-benzyl salicylamide derivatives

0476525 - ÚEB 2018 RIV AE eng J - Článek v odborném periodiku
Dušek, J. - Imramovský, A. - Pauk, K. - Jorda, Radek - Řezníčková, Eva - Kryštof, Vladimír
Synthesis and antiproliferative activities of novel O-benzyl salicylamide derivatives.
Letters in Drug Design & Discovery. Roč. 14, č. 6 (2017), s. 662-671. ISSN 1570-1808. E-ISSN 1875-628X
Grant CEP: GA ČR(CZ) GA15-15264S; GA MŠMT(CZ) LO1204
Institucionální podpora: RVO:61389030
Klíčová slova: Amines * Antiproliferative activity * Cytotoxic activity * Pharmacological activity * Salicylamides
Obor OECD: Organic chemistry
Impakt faktor: 0.924, rok: 2017

On the basis that various substituted salicylamides have shown interesting biological properties, we designed and synthesized new salicylamide derivatives with dipeptide moieties. Methods: The synthesis was based on the gradual building of target molecules and provided optically pure compounds. Conclusion: The obtained compounds were tested for their antiproliferative effect against three leukaemia cell lines in vitro and displayed GI50 values in the mid-micromolar range.
Trvalý link: http://hdl.handle.net/11104/0273005