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Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux
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SYSNO ASEP 0467237 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux Tvůrce(i) Pachnikova, G. (CZ)
Uldrijan, S. (CZ)
Imramovský, A. (CZ)
Kryštof, Vladimír (UEB-Q) RID, ORCID
Slaninová, I. (CZ)Celkový počet autorů 5 Zdroj.dok. Toxicology in Vitro. - : Elsevier - ISSN 0887-2333
Roč. 37, DEC (2016), s. 70-78Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova hepatocellular-carcinoma cells ; sorafenib ; apoptosis ; death ; maturation ; membrane ; melanoma ; Actin ; Autophagy ; Melanoma ; Metabolic stress ; Sorafenib ; Substituted 2-hydroxy-N-(arylalkyl)benzamide Vědní obor RIV CE - Biochemie Institucionální podpora UEB-Q - RVO:61389030 UT WOS 000387198300009 DOI 10.1016/j.tiv.2016.09.006 Anotace N-((R)-1-(4-chlorophenylcarbamoy1)-2-phenylethyl)-5-chloro-2-hydroxybenzamide (Compound 6k), was recently isolated during the preparation of amino adds esters with salicylanilides. We show here that 6k disrupts the dynamics of actin cytoskeleton in human melanoma cells, affecting processes essential for the maintenance and expansion of tumours such as cell adlision, motility, proliferation, vesicular transport, and autophagic flux. We demonstrated that inhibition of autophagy by 6k increased the sensitivity of melanoma cells to metabolic stress induced by rotenone or nutrient starvation and potentiated the anti-proliferative activity of small molecule multikinase inhibitor sorafenib. Since autophagy plays an important role in survival of cancer cells subjected to chemotherapy, the above mentioned properties are interesting from clinical point of view as 6k could promote metabolic stress within the tumour microenvironment and potentiate the effect of cytostatics in combination therapy. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2017
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