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Influence of polyacrylic acid nanoparticles on the elastic properties of RBCs membranes in patients with diabetes mellitus type 2
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SYSNO ASEP 0453579 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Influence of polyacrylic acid nanoparticles on the elastic properties of RBCs membranes in patients with diabetes mellitus type 2 Tvůrce(i) Melnikova, G.B. (BY)
Kuzhel, N.S. (BY)
Tolstaya, T.N. (BY)
Konstantinova, E.E. (BY)
Drozd, E.S. (BY)
Shisko, O.N. (BY)
Mokhort, T.G. (BY)
Antonova, N. (BG)
Říha, Pavel (UH-J) SAI, ORCID, RID
Kowalczuk, A. (PL)
Koseva, N. (BG)Zdroj.dok. Series on biomechanics. - Sofia : Bulgarian Academy of Sciences - ISSN 1313-2458
Roč. 29, č. 4 (2015), s. 12-19Poč.str. 8 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. BG - Bulharsko Klíč. slova red blood cells ; nanoparticles ; poly(acrylic acid) ; elasticity modulus ; atomic force microscopy Vědní obor RIV BK - Mechanika tekutin Institucionální podpora UH-J - RVO:67985874 Anotace The influence of polyacrylic acid (PAA) derived nanoparticles, a star shaped macromolecules with/nhydrodynamic radius of 14 nm, on the structure and mechanical properties of red blood cells (RBCs) membranes in/npatients with diabetes mellitus type 2 by AFM method has been studied. Their behavior has been compared to that/nof linear PAAs with different degrees of polymerization. Significant changes in the structure of RBCs membranes/ndid not occur and traces of polymer chains or nanoparticles were not found. It was shown, that changes of the/nelasticity modulus were observed after cells incubated in the presence of linear PAA with Mn =20000 Da and/n225000 Da, due to the interaction of polymer chains with the components of the cell membrane. The star shaped/nNPs with Mn = 57000 Da lead to the smallest changes in the structure and properties cells membrane. Thus, these/nNPs can be recommended for drug delivery applications. Pracoviště Ústav pro hydrodynamiku Kontakt Soňa Hnilicová, hnilicova@ih.cas.cz, Tel.: 233 109 003 Rok sběru 2016
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