Počet záznamů: 1
Potential Clinical Uses of CDK Inhibitors: Lessons from Synthetic Lethality Screens
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SYSNO ASEP 0450910 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Potential Clinical Uses of CDK Inhibitors: Lessons from Synthetic Lethality Screens Tvůrce(i) Vymětalová, Ladislava (UEB-Q)
Kryštof, Vladimír (UEB-Q) RID, ORCIDZdroj.dok. Medicinal Research Reviews. - : Wiley - ISSN 0198-6325
Roč. 35, č. 6 (2015), s. 1156-1174Poč.str. 19 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova cyclin-dependent kinase ; inhibitor ; cancer Vědní obor RIV FR - Farmakologie a lékárnická chemie CEP LO1204 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA15-15264S GA ČR - Grantová agentura ČR Institucionální podpora UEB-Q - RVO:61389030 UT WOS 000362795200003 DOI 10.1002/med.21354 Anotace Developments in genetic and genomic technology have produced vast quantities of data that are gradually yielding new insights into fundamental cellular and molecular processes. In particular, they have revealed some differences between normal and transformed cells that could potentially be exploited to develop targeted, personalized cancer therapies with unprecedented efficiencies. This review summarizes recent findings from synthetic lethality (SL) screens against cyclin-dependent kinases (CDKs) that can be targeted with small molecule kinase inhibitors. SL screens can be used to identify cancers sensitive to CDK inhibitors. Several SL partners of specific CDKs have been identified, including MYC, K-Ras, VHL, PI3K, and PARP, all of which are discussed in the review. CDK inhibitors have been in clinical trials for nearly 20 years and it has become clear that effective therapy using these compounds will require careful selection of patients with respect to the specific molecular phenotype of their disease. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2016
Počet záznamů: 1