Počet záznamů: 1
Holocentromeres in Rhynchospora are associated with genome-wide centromere-specific repeat arrays interspersed among euchromatin
- 1.0450286 - BC 2016 RIV US eng J - Článek v odborném periodiku
Marques, A. - Ribeiro, T. - Neumann, Pavel - Macas, Jiří - Novák, Petr - Schubert, V. - Pellino, M. - Fuchs, J. - Ma, W. - Kuhlmann, M. - Brandt, R. - Vanzela, A.L.L. - Beseda, Tomáš - Šimková, Hana - Pedrosa-Harand, A. - Houben, A.
Holocentromeres in Rhynchospora are associated with genome-wide centromere-specific repeat arrays interspersed among euchromatin.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 112, č. 44 (2015), s. 13633-13638. ISSN 0027-8424. E-ISSN 1091-6490
Grant CEP: GA ČR GBP501/12/G090; GA MŠMT(CZ) LO1204
Institucionální podpora: RVO:60077344 ; RVO:61389030
Klíčová slova: Centromere * satellite DNA * holokinetic * chromosome
Kód oboru RIV: EB - Genetika a molekulární biologie; EB - Genetika a molekulární biologie (UEB-Q)
Impakt faktor: 9.423, rok: 2015
Holocentric chromosomes lack a primary constriction, in contrast to monocentrics. They form kinetochores distributed along almost the entire poleward surface of the chromatids, to which spindle fibers attach. No centromere-specific DNA sequence has been found for any holocentric organism studied so far. It was proposed that centromeric repeats, typical for many monocentric species, could not occur in holocentrics, most likely because of differences in the centromere organization. Here we show that the holokinetic centromeres of the Cyperaceae Rhynchospora pubera are highly enriched by a centromeric histone H3 variant-interacting centromere-specific satellite family designated “Tyba” and by centromeric retrotransposons (i.e., CRRh) occurring as genome-wide interspersed arrays. Centromeric arrays vary in length from 3 to 16 kb and are intermingled with gene-coding sequences and transposable elements.
Trvalý link: http://hdl.handle.net/11104/0251624
Počet záznamů: 1