Počet záznamů: 1
Synthesis and biological activity of new homolupanes and homolupane saponins
- 1.
SYSNO ASEP 0446691 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Synthesis and biological activity of new homolupanes and homolupane saponins Tvůrce(i) Sidoryk, K. (PL)
Korda, A. (PL)
Rárová, Lucie (UEB-Q) RID, ORCID
Oklešťková, Jana (UEB-Q) RID, ORCID, SAI
Strnad, Miroslav (UEB-Q) RID, ORCID
Cmoch, P. (PL)
Pakulski, Z. (PL)
Gwardiak, K. (PL)
Karczewski, R. (PL)
Luboradzki, R. (PL)Zdroj.dok. Tetrahedron. - : Elsevier - ISSN 0040-4020
Roč. 71, č. 13 (2015), s. 2004-2012Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Homobetulin ; Homobetulinic acid ; Glycosylation Vědní obor RIV EB - Genetika a molekulární biologie CEP LO1204 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UEB-Q - RVO:61389030 UT WOS 000352747900015 DOI 10.1016/j.tet.2015.02.008 Anotace A concise synthesis of 28a-homolupane triterpenes and the corresponding saponins containing D-mannose, D-idose, D-arabinose, and L-rhamnose moieties was elaborated. The overall synthesis of the new triterpenes involved three linear steps starting from readily available 3-O-acetyl-betulinal: elongation of the carbon chain by Wittig reaction followed by enol ether hydrolysis and reduction (or oxidation) of the elongated aldehyde. Saponins were obtained by glycosylation of triterpenes with classical Schmidt donors. Cytotoxic activities of new lupane and homolupane compounds were evaluated in vitro. Several triterpenes and the corresponding saponins exhibited an interesting cytotoxic activity profile against human cancer cell lines. Influence of the side-chain structure and substituents on the cytotoxicity of betulin and homobetulin derivatives was investigated. These results open the way to the synthesis of various lupane-type triterpene and saponin derivatives as potential anticancer compounds. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2016
Počet záznamů: 1