Počet záznamů: 1
X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids
- 1.
SYSNO ASEP 0424947 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids Tvůrce(i) Bhattacharyya, Tanmoy (UMG-J)
Reifová, R. (CZ)
Gregorová, Soňa (UMG-J)
Šimeček, Petr (UMG-J)
Gergelits, Václav (UMG-J)
Mistrik, M. (CZ)
Martincová, Iva (UBO-W) ORCID
Piálek, Jaroslav (UBO-W) RID, ORCID, SAI
Forejt, Jiří (UMG-J) RID, ORCIDZdroj.dok. PLoS Genetics. - : Public Library of Science - ISSN 1553-7404
Roč. 10, č. 2 (2014), e1004088Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova hybrid sterility ; meiotic asynapsis ; chromosome substitution strains Vědní obor RIV EB - Genetika a molekulární biologie CEP Premium Academiae of the Academy of Sciences of the Czech Republic GA AV ČR - Akademie věd LD11079 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA206/08/0640 GA ČR - Grantová agentura ČR ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UBO-W - RVO:68081766 ; UMG-J - RVO:68378050 UT WOS 000332021500056 DOI 10.1371/journal.pgen.1004088 Anotace Genomes of newly emerging species restrict their gene exchange with related taxa in order to secure integrity. Hybrid sterility is one of the reproductive isolation mechanisms restricting gene flow between closely related, sexually reproducing organisms. We showed that hybrid sterility between two closely related mouse subspecies is executed by a failure of meiotic synapsis of orthologous chromosomes in F1 hybrid males. The asynapsis of orthologous chromosomes occurred in meiosis of male and female hybrids, though only males were sterile due to trans-acting male-specific hybrid sterility genes. We located one of the two major hybrid sterility genes to a 4.7 Mb interval on Chromosome X, showed that it controls male sterility by modulating the extent of meiotic asynapsis and using the inter-subspecific chromosome substitution strains we refuted the simple interpretation of dominance theory of Haldane's rule. A new working hypothesis posits male sterility of mouse inter-subsubspecific F1 hybrids as a consequence of meiotic chromosome asynapsis caused by the cis-acting mismatch between orthologous chromosomes modulated by the trans-acting hybrid male sterility genes. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2014
Počet záznamů: 1