Počet záznamů: 1
Heat Shock-Induced Accumulation of Translation Elongation and Termination Factors Precedes Assembly of Stress Granules in S. cerevisiae
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SYSNO ASEP 0392739 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Heat Shock-Induced Accumulation of Translation Elongation and Termination Factors Precedes Assembly of Stress Granules in S. cerevisiae Tvůrce(i) Groušl, Tomáš (MBU-M) RID, ORCID
Malcová, Ivana (MBU-M) RID, ORCID
Pompach, Petr (MBU-M) RID, ORCID
Frýdlová, Ivana (MBU-M)
Slabá, Renata (MBU-M) RID
Senohrábková, Lenka (MBU-M) RID
Nováková, Lenka (MBU-M)
Hašek, Jiří (MBU-M) RID, ORCIDZdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 8, č. 2 (2013), e57083Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova CYTOPLASMIC PROCESSING BODIES ; GUANINE-NUCLEOTIDE EXCHANGE ; EUKARYOTIC MESSENGER-RNAS Vědní obor RIV EE - Mikrobiologie, virologie CEP GA204/09/1924 GA ČR - Grantová agentura ČR GAP305/12/0480 GA ČR - Grantová agentura ČR GPP305/10/P253 GA ČR - Grantová agentura ČR Institucionální podpora MBU-M - RVO:61388971 UT WOS 000316849500064 DOI 10.1371/journal.pone.0057083 Anotace In response to severe environmental stresses eukaryotic cells shut down translation and accumulate components of the translational machinery in stress granules (SGs). Since they contain mainly mRNA, translation initiation factors and 40S ribosomal subunits, they have been referred to as dominant accumulations of stalled translation preinitiation complexes. Here we present evidence that the robust heat shock-induced SGs of S. cerevisiae also contain translation elongation factors eEF3 (Yef3p) and eEF1B gamma 2 (Tef4p) as well as translation termination factors eRF1 (Sup45p) and eRF3 (Sup35p). Despite the presence of the yeast prion protein Sup35 in heat shock-induced SGs, we found out that its prion-like domain is not involved in the SGs assembly Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2014
Počet záznamů: 1