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A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants
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SYSNO ASEP 0380744 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants Tvůrce(i) Barbez, E. (BE)
Kubeš, Martin (UEB-Q) RID, ORCID
Rolčík, Jakub (UEB-Q)
Béziat, Ch. (AU)
Pěnčík, Aleš (UEB-Q) ORCID, RID, SAI
Wang, B. (CH)
Rosquete, M. R. (BE)
Zhu, J. (CH)
Dobrev, Petre (UEB-Q) RID, ORCID
Lee, Y. (CH)
Zažímalová, Eva (UEB-Q) RID, ORCID
Petrášek, Jan (UEB-Q) RID, ORCID
Geisler, M. (CH)
Friml, J. (BE)
Kleine-Vehn, J. (BE)Zdroj.dok. Nature. - : Palgrave Macmillan - ISSN 0028-0836
Roč. 485, č. 7396 (2012), s. 119-124Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova auxin ; auxin homeostasis ; PILS (PIN-likes) Vědní obor RIV EB - Genetika a molekulární biologie CEP LC06034 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GAP305/11/2476 GA ČR - Grantová agentura ČR GAP305/11/0797 GA ČR - Grantová agentura ČR CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000303451900046 DOI 10.1038/nature11001 Anotace The phytohormone auxin acts as a prominent signal, providing, by its local accumulation or depletion in selected cells, a spatial and temporal reference for changes in the developmental program. The distribution of auxin depends on both auxin metabolism (biosynthesis, conjugation and degradation) and cellular auxin transport. We identified in silico a novel putative auxin transport facilitator family, called PIN-LIKES (PILS). Here we illustrate that PILS proteins are required for auxin-dependent regulation of plant growth by determining the cellular sensitivity to auxin. PILS proteins regulate intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signalling. PILS activity affects the level of endogenous auxin indole-3-acetic acid (IAA), presumably via intracellular accumulation and metabolism. Our findings reveal that the transport machinery to compartmentalize auxin within the cell is of an unexpected molecular complexity and demonstrate this compartmentalization to be functionally important for a number of developmental processes. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2013
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