Počet záznamů: 1
GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis
- 1.
SYSNO ASEP 0365270 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis Tvůrce(i) Bohmdorfer, G. (AT)
Schleiffer, A. (AT)
Brunmeir, R. (SG)
Ferscha, S. (AT)
Nizhynska, V. (AT)
Kozák, Jaroslav (UEB-Q)
Angelis, Karel (UEB-Q) RID, ORCID
Kreil, D. P. (AT)
Schweizer, D. (AT)Zdroj.dok. Plant Journal. - : Wiley - ISSN 0960-7412
Roč. 67, č. 3 (2011), s. 420-433Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova structural maintenance of chromosomes ; DNA repair ; somatic homologous recombination Vědní obor RIV EI - Biotechnologie a bionika CEP 1M0505 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LC06004 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000293176600004 DOI 10.1111/j.1365-313X.2011.04604.x Anotace DNA double-strand breaks (DSBs) pose one of the most severe threats to genome integrity, potentially leading to cell death. After detection of a DSB, the DNA damage and repair response is initiated and the DSB is repaired by non-homologous end joining and/or homologous recombination. Many components of these processes are still unknown in Arabidopsis thaliana. In this work, we characterized gamma-irradiation and mitomycin C induced 1 (GMI1), a member of the SMC-hinge domain-containing protein family. RT-PCR analysis and promoter-GUS fusion studies showed that gamma-irradiation, the radio-mimetic drug bleocin, and the DNA cross-linking agent mitomycin C strongly enhance GMI1 expression particularly in meristematic tissues. The induction of GMI1 by gamma-irradiation depends on the signalling kinase Ataxia telangiectasia-mutated (ATM) but not on ATM and Rad3-related (ATR). Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2012
Počet záznamů: 1