Počet záznamů: 1
Role of FAT/CD36 in novel PKC isoform activation in heart of spontaneously hypertensive rats
- 1.0365731 - FGÚ 2012 RIV US eng J - Článek v odborném periodiku
Klevstig, M. J. - Marková, I. - Burianová, J. - Kazdová, L. - Pravenec, Michal - Nováková, O. - Novák, F.
Role of FAT/CD36 in novel PKC isoform activation in heart of spontaneously hypertensive rats.
Molecular and Cellular Biochemistry. Roč. 357, 1-2 (2011), s. 163-169. ISSN 0300-8177. E-ISSN 1573-4919
Grant CEP: GA ČR(CZ) GD305/08/H037; GA MŠMT(CZ) ME08006
Grant ostatní: Univerzita Karlova(CZ) SVV33779266
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: CD36 * novel PKC * spontaneously hypertensive rat * insulin resistance
Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
Impakt faktor: 2.057, rok: 2011
Searching for a possible role of novel protein kinase C (nPKC) in heart with disrupted energy balance, we compared the insulin-resistant spontaneously hypertensive rats (SHR), which carry a nonfunctional variant of the fatty acid transporter FAT/CD36, with the less insulin-resistant congenic strain SHR-4 that is genetically identical except for a segment on chromosome 4 including a wild-type gene for a functional FAT/CD36. Our results demonstrate that reduced insulin resistance in SHR-4 rats is associated with the insulin signaling pathway involving nPKCs
Trvalý link: http://hdl.handle.net/11104/0200903
Počet záznamů: 1