Počet záznamů: 1  

Negative relationships between cellular immune response, Mhc class II heterozygosity and secondary sexual trait in the montane water vole

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    0337712 - ÚBO 2011 RIV GB eng J - Článek v odborném periodiku
    Charbonnel, N. - Bryja, Josef - Galan, M. - Deter, J. - Tollenaere, C. - Chaval, Y. - Morand, S. - Cosson, J.-F.
    Negative relationships between cellular immune response, Mhc class II heterozygosity and secondary sexual trait in the montane water vole.
    Evolutionary Applications. Roč. 3, č. 3 (2010), s. 279-290. ISSN 1752-4571. E-ISSN 1752-4571
    GRANT EU: European Commission(XE) 10284 - EDEN
    Výzkumný záměr: CEZ:AV0Z60930519
    Klíčová slova: abundance cycles * Dqa and Drb * immunocompetence handicap * Mhc class II genes * parasite-mediated balancing selection * sexual selection
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 5.145, rok: 2010

    Heterogeneities in immune responsiveness may affect key epidemiological parameters and the dynamics of pathogens. We analysed the influence of Major histocompatibility complex (Mhc) genes and epigamic traits on the response to phytohaemagglutinin in males from cyclic populations of the montane water vole (Arvicola scherman). We found a negative relationship between Mhc hetetozygosity and response to phytohaemagglutinin, mediated by a specific Mhc genotype (Arte-Dqa-05 homozygous genotype being a ‘good’ Mhc variant in terms of immunogenetic quality). The development of the scent glands seems to be an honest signal for mate choice as it is negatively correlated with helminth load. The ‘good gene’ hypothesis was not validated as Arte-Dqa-05 homozygous males did not exhibit larger glands. Besides, the negative relationship observed between the size of these glands and the response to phytohaemagglutinin, mainly for Mhc homozygotes, corroborates the immunocompetence handicap hypothesis.
    Trvalý link: http://hdl.handle.net/11104/0181645

     
     
Počet záznamů: 1  

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