Počet záznamů: 1
Widespread adaptive introgression of major histocompatibility complex genes across vertebrate hybrid zones
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SYSNO ASEP 0599799 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Widespread adaptive introgression of major histocompatibility complex genes across vertebrate hybrid zones Tvůrce(i) Gaczorek, T. (PL)
Dudek, K. (PL)
Fritz, U. (DE)
Bahri-Sfar, L. (TN)
Baird, Stuart J. E. (UBO-W) RID, ORCID, SAI
Bonhomme, F. (FR)
Dufresnes, C. (FR)
Gvoždík, Václav (UBO-W) RID, SAI, ORCID
Irwin, D. (CA)
Kotlík, Petr (UZFG-Y) RID, ORCID
Marková, Silvia (UZFG-Y) ORCID, RID
McGinnity, P. (IE)
Migalska, M. (PL)
Moravec, J. (CZ)
Natola, L. (CA)
Pabijan, M. (PL)
Phillips, K. P. (CA)
Schöneberg, Y. (DE)
Souissi, A. (TN)
Radwan, J. (PL)
Babik, W. (PL)Celkový počet autorů 21 Číslo článku msae201 Zdroj.dok. Molecular Biology and Evolution. - : Oxford University Press - ISSN 0737-4038
Roč. 41, č. 10 (2024)Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova adaptation ; host–pathogen coevolution ; hybridization ; introgression ; MHC Vědní obor RIV EG - Zoologie Obor OECD Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology CEP GA18-24544S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UBO-W - RVO:68081766 ; UZFG-Y - RVO:67985904 UT WOS 001334598500001 EID SCOPUS 85206400430 DOI https://doi.org/10.1093/molbev/msae201 Anotace Interspecific introgression is a potentially important source of novel variation of adaptive significance. Although multiple cases of adaptive introgression are well documented, broader generalizations about its targets and mechanisms are lacking. Multiallelic balancing selection, particularly when acting through rare allele advantage, is an evolutionary mechanism expected to favor adaptive introgression. This is because introgressed alleles are likely to confer an immediate selective advantage, facilitating their establishment in the recipient species even in the face of strong genomic barriers to introgression. Vertebrate major histocompatibility complex genes are well-established targets of long-term multiallelic balancing selection, so widespread adaptive major histocompatibility complex introgression is expected. Here, we evaluate this hypothesis using data from 29 hybrid zones formed by fish, amphibians, squamates, turtles, birds, and mammals at advanced stages of speciation. The key prediction of more extensive major histocompatibility complex introgression compared to genome-wide introgression was tested with three complementary statistical approaches. We found evidence for widespread adaptive introgression of major histocompatibility complex genes, providing a link between the process of adaptive introgression and an underlying mechanism. Our work identifies major histocompatibility complex introgression as a general mechanism by which species can acquire novel, and possibly regain previously lost, variation that may enhance defense against pathogens and increase adaptive potential. Pracoviště Ústav biologie obratlovců Kontakt Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Rok sběru 2025 Elektronická adresa https://academic.oup.com/mbe/article-pdf/41/10/msae201/59744748/msae201.pdf
Počet záznamů: 1