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Membrane permeability and responsiveness drive performance: linking structural features with the antitumor effectiveness of doxorubicin-loaded stimuli-triggered polymersomes
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SYSNO ASEP 0587483 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Membrane permeability and responsiveness drive performance: linking structural features with the antitumor effectiveness of doxorubicin-loaded stimuli-triggered polymersomes Tvůrce(i) Jäger, Eliezer (UMCH-V) ORCID, RID
Černoch, Peter (UMCH-V) RID, ORCID
Vragović, Martina (UMCH-V)
Calumby Albuquerque, Lindomar J. (UMCH-V)
Sincari, Vladimir (UMCH-V) ORCID, RID
Heizer, T. (CZ)
Jäger, Alessandro (UMCH-V) RID, ORCID
Kučka, Jan (UMCH-V) RID, ORCID
Šebestová Janoušková, Olga (UMCH-V) RID, ORCID, SAI
Pavlova, Ewa (UMCH-V) RID
Šefc, L. (CZ)
Giacomelli, F. C. (BR)Zdroj.dok. Biomacromolecules. - : American Chemical Society - ISSN 1525-7797
Roč. 25, č. 7 (2024), s. 4192-4202Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova polymersomes ; permeability ; responsiveness Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP GC20-15479J GA ČR - Grantová agentura ČR LM2023053 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy EH22_008/0004607 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GJ20-15077Y GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 001255556300001 EID SCOPUS 85196939724 DOI https://doi.org/10.1021/acs.biomac.4c00282 Anotace The permeability and responsiveness of polymer membranes are absolutely relevant in the design of polymersomes for cargo delivery. Accordingly, we herein correlate the structural features, permeability, and responsiveness of doxorubicin-loaded (DOX-loaded) nonresponsive and stimuli-responsive polymersomes with their in vitro and in vivo antitumor performance. Polymer vesicles were produced using amphiphilic block copolymers containing a hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) segment linked to poly[N-(4-isopropylphenylacetamide)ethyl methacrylate] (PPPhA, nonresponsive block), poly[4-(4,4,5,5-tetra-methyl-1,3,2-dioxaborolan-2-yl)benzyl methacrylate] [PbAPE, reactive oxygen species (ROS)-responsive block], or poly[2-(diisopropylamino)ethyl methacrylate] (PDPA, pH-responsive block). The PDPA-based polymersomes demonstrated outstanding biological performance with antitumor activity notably enhanced compared to their counterparts. We attribute this behavior to a fast-triggered DOX release in acidic tumor environments as induced by pH-responsive polymersome disassembly at pH < 6.8. Possibly, an insufficient ROS concentration in the selected tumor model attenuates the rate of ROS-responsive vesicle degradation, whereas the nonresponsive nature of the PPPhA block remarkably impacts the performance of such potential nanomedicines. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2025 Elektronická adresa https://pubs.acs.org/doi/10.1021/acs.biomac.4c00282
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