The deletion of AQP4 and TRPV4 affects astrocyte swelling/volume recovery in response to ischemia-mimicking pathologies

0585938 - ÚEM 2025 RIV CH eng J - Článek v odborném periodiku
Heřmanová, Zuzana - Valihrach, Lukáš - Kriška, Ján - Maheta, M. - Turečková, Jana - Kubišta, M. - Anděrová, Miroslava
The deletion of AQP4 and TRPV4 affects astrocyte swelling/volume recovery in response to ischemia-mimicking pathologies.
Frontiers in Cellular Neuroscience. Roč. 18, May (2024). E-ISSN 1662-5102
Grant CEP: GA ČR(CZ) GA20-05770S; GA MŠMT(CZ) LX22NPO5107; GA MŠMT(CZ) LM2023050
Institucionální podpora: RVO:68378041
Klíčová slova: aquaporin 4 * transient receptor potential vanilloid 4 * astrocytes * brain edema * ischemia
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 5.3, rok: 2022
https://www.frontiersin.org/articles/10.3389/fncel.2024.1393751/full

Astrocytic Transient receptor potential vanilloid 4 (TRPV4)
channels, together with Aquaporin 4 (AQP4), are suspected to be the key players
in cellular volume regulation, and therefore may affect the development and
severity of cerebral edema during ischemia. In this study, we examined astrocytic
swelling/volume recovery in mice with TRPV4 and/or AQP4 deletion in response
to in vitro ischemic conditions, to determine how the deletion of these channels
can affect the development of cerebral edema.
Trvalý link: https://hdl.handle.net/11104/0353574