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Silver-sulfamethazine-conjugated beta-cyclodextrin/dextran-coated magnetic nanoparticles for pathogen inhibition
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SYSNO ASEP 0583046 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Silver-sulfamethazine-conjugated beta-cyclodextrin/dextran-coated magnetic nanoparticles for pathogen inhibition Tvůrce(i) Shatan, Anastasiia-Bohdana (UMCH-V) RID, ORCID
Patsula, Vitalii (UMCH-V) RID, ORCID
Macková, Hana (UMCH-V) RID
Mahun, Andrii (UMCH-V) ORCID
Lehotská, R. (SK)
Piecková, E. (SK)
Horák, Daniel (UMCH-V) RID, ORCIDČíslo článku 371 Zdroj.dok. Nanomaterials. - : MDPI
Roč. 14, č. 4 (2024)Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova superparamagnetic iron oxide nanoparticles ; β-cyclodextrin ; silver-sulfamethazine Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP LX22NPO5102 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 001173096900001 EID SCOPUS 85185697822 DOI 10.3390/nano14040371 Anotace In the fight against antibiotic resistance, which is rising to dangerously high levels worldwide, new strategies based on antibiotic-conjugated biocompatible polymers bound to magnetic nanoparticles that allow the drug to be manipulated and delivered to a specific target are being proposed. Here, we report the direct surface engineering of nontoxic iron oxide nanoparticles (IONs) using biocompatible dextran (Dex) covalently linked to β-cyclodextrin (β-CD) with the ability to form non-covalent complexes with silver-sulfamethazine (SMT-Ag). To achieve a good interaction of β-CD-modified dextran with the surface of the nanoparticles, it was functionalized with diphosphonic acid (DPA) that provides strong binding to Fe atoms. The synthesized polymers and nanoparticles were characterized by various methods, such as nuclear magnetic resonance (NMR), Fourier transform infrared (FTIR) and ultraviolet–visible (UV–Vis) spectroscopies, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), atomic absorption spectroscopy (AAS), dynamic light scattering (DLS), etc. The resulting magnetic ION@DPA-Dex-β-CD-SMT-Ag nanoparticles were colloidally stable in water and contained 24 μg of antibiotic per mg of the particles. When tested for in vitro antimicrobial activity on Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria and fungi (yeast Candida albicans and mold Aspergillus niger), the particles showed promising potential.
Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2025 Elektronická adresa https://www.mdpi.com/2079-4991/14/4/371
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