Počet záznamů: 1
Highly hydrophilic methacrylamide-based copolymers as precursors for polymeric nanomedicines containing anthracyclines
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SYSNO ASEP 0580623 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Highly hydrophilic methacrylamide-based copolymers as precursors for polymeric nanomedicines containing anthracyclines Tvůrce(i) Pytlíková, Sára (UMCH-V)
Pechar, Michal (UMCH-V) RID, ORCID
Chytil, Petr (UMCH-V) RID, ORCID
Studenovský, Martin (UMCH-V) RID, ORCID
Pola, Robert (UMCH-V) RID, ORCID
Kotrchová, Lenka (UMCH-V) RID, ORCID
Konefal, Rafal (UMCH-V) RID, ORCID
Čtveráčková, Lucie (UMCH-V)
Laga, Richard (UMCH-V) RID, ORCID
Pankrác, J. (CZ)
Gao, S. (JP)
Jiang, B. (JP)
Yang, K. (JP)
Fang, J. (JP)
Filipová, Marcela (UMCH-V) RID, ORCID
Etrych, Tomáš (UMCH-V) RID, ORCIDČíslo článku 112756 Zdroj.dok. European Polymer Journal. - : Elsevier - ISSN 0014-3057
Roč. 205, 7 February (2024)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova drug delivery systems ; polymer drug carriers ; N‑(1,3‑dihydroxyprop-2-yl) methacrylamide Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP LX22NPO5102 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA22-12483S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 001159005300001 EID SCOPUS 85182421277 DOI 10.1016/j.eurpolymj.2024.112756 Anotace The crucial limitation of most low molecular weight cytostatic drugs, including anthracyclines, is their nonspecific biodistribution causing severe adverse effects during cancer treatment. Recently, nanomedicines such as polymer-based systems have been developed as advanced drug delivery systems. Herein, we report the design, synthesis, and characterization of highly water-soluble polymer-carriers based on N‑(1,3‑dihydroxyprop-2-yl)methacrylamide (DHPMA). Polymers differing in molecular weight, hydrodynamic size, and dispersity were synthesized via free or controlled radical polymerization and conjugated to an anthracycline drug pirarubicin (THP) via a pH-sensitive hydrazone bond achieving up to 21 wt% of THP. The DHPMA copolymers were extensively compared to the well-known drug delivery vectors, N-(2-hydroxypropyl)methacrylamide (HPMA)-based copolymers. Importantly, DHPMA-based conjugates showed excellent hydrophilicity exceeding that of HPMA-based copolymers and did not aggregate even after loading with THP reaching 21 wt%. The DHPMA-based polymer nanomedicines exhibited excellent cytotoxicity, body biodistribution, tumor accumulation, and antitumor efficacy, significantly reducing the side effects and toxicity comparable to HPMA-based systems, thus demonstrating their applicability and suitability as efficient drug carriers. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2025 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S001430572400017X?via%3Dihub
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