Počet záznamů: 1
Distance from main arteries influences microstructural and functional brain tissue characteristics
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SYSNO ASEP 0579949 Druh ASEP J - Článek v odborném periodiku Zařazení RIV Záznam nebyl označen do RIV Poddruh J Článek ve WOS Název Distance from main arteries influences microstructural and functional brain tissue characteristics Tvůrce(i) Weiss, V. (CZ)
Kokošová, V. (CZ)
Valenta, Zdeněk (UIVT-O) RID, SAI, ORCID
Doležalová, I. (CZ)
Baláž, M. (CZ)
Mangia, S. (US)
Michaeli, S. (US)
Vojtíšek, L. (CZ)
Nestrašil, I. (US)
Herzig, R. (CZ)
Filip, P. (CZ)Celkový počet autorů 11 Zdroj.dok. Neuroimage. - : Elsevier - ISSN 1053-8119
Roč. 285, January 2024 (2024), s. 120502Poč.str. 7 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Quantitative MRI ; Relaxometry ; Diffusion weighted imaging ; Resting-state functional ; MRI ; Arterial distance Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Clinical neurology CEP LM2018129 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UIVT-O - RVO:67985807 UT WOS 001139614000001 EID SCOPUS 85180360461 DOI 10.1016/j.neuroimage.2023.120502 Anotace Given the substantial dependence of neurons on continuous supply of energy, the distribution of major cerebral arteries opens a question whether the distance from the main supply arteries constitutes a modulating factor for the microstructural and functional properties of brain tissue. To tackle this question, multimodal MRI acquisitions of 102 healthy volunteers over the full adult age span were utilised. Relaxation along a fictitious field in the rotating frame of rank n = 4 (RAFF4), adiabatic T1ρ, T2ρ, and intracellular volume fraction (fICVF) derived from diffusion-weighted imaging were implemented to quantify microstructural (cellularity, myelin density, iron concentration) tissue characteristics and degree centrality and fractional amplitude of low-frequency fluctuations to probe for functional metrics. Inverse correlation of arterial distance with robust homogeneity was detected for T1ρ, T2ρ and RAFF4 for cortical grey matter and white matter, showing substantial complex microstructural differences between brain tissue close and farther from main arterial trunks. Albeit with wider variability, functional metrics pointed to increased connectivity and neuronal activity in areas farther from main arteries. Surprisingly, multiple of these microstructural and functional distance-based gradients diminished with higher age, pointing to uniformization of brain tissue with ageing. All in all, this pilot study provides a novel insight on brain regionalisation based on artery distance, which merits further investigation to validate its biological underpinnings. Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2025 Elektronická adresa https://doi.org/10.1016/j.neuroimage.2023.120502
Počet záznamů: 1