Design and synthesis of new molecular tools to probe cytosolic proteins in bacteria resistant to rifamycin antibiotics

0578949 - ÚOCHB 2024 RIV CZ eng A - Abstrakt
Mojr, Viktor - Sudzinová, Petra - Hubálek, Martin - Krásný, Libor - Rejman, Dominik
Design and synthesis of new molecular tools to probe cytosolic proteins in bacteria resistant to rifamycin antibiotics.
Czech Chemical Society Symposium Series. Roč. 21, č. 5 (2023), s. 179. ISSN 2336-7202.
[Annual meeting of the National Institute of Virology and Bacteriology (NIVB) /2./. 02.10.2023-05.10.2023, Kutná Hora]
Grant CEP: GA MŠMT(CZ) LX22NPO5103
Institucionální podpora: RVO:61388963 ; RVO:61388971
Klíčová slova: rifamycin * resistance
Obor OECD: Organic chemistry; Microbiology (MBU-M)
http://www.ccsss.cz/index.php/ccsss/issue/view/41/75

Rifamycin-derived antibiotics are highly efficient inhibitors of prokaryotic DNA-dependent RNA polymerase (RNAP) used in treatment of many bacterial infections, including tuberculosis. During exposure, however, bacteria develop resistance to antibiotics, and several modifications of rifamycin skeleton that inhibit RNAP binding have already been discovered. A photo-crosslinking probe 1(Fig. 1) with biotin handle based on rifamycin B was recently used for identifying specific protein that displaces antibiotic from RNAP in Streptomyces venezulae.
Trvalý link: https://hdl.handle.net/11104/0347852