Počet záznamů: 1
Lipophosphonoxins—A Novel Group of Broad Spectrum Antibacterial Compounds
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SYSNO ASEP 0577714 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Lipophosphonoxins—A Novel Group of Broad Spectrum Antibacterial Compounds Tvůrce(i) Šebek, V. (CZ)
Anzenbacher, P. (CZ)
Rejman, Dominik (UOCHB-X) RID, ORCID
Špičáková, A. (CZ)
Kolář, M. (CZ)Číslo článku 2395 Zdroj.dok. Pharmaceutics. - : MDPI
Roč. 15, č. 10 (2023)Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova lipophosphonoxin ; antibiotics ; resistance ; LPPOs ; antimicrobial resistance Obor OECD Microbiology CEP LX22NPO5103 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA22-08857S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 001095188800001 EID SCOPUS 85175026103 DOI 10.3390/pharmaceutics15102395 Anotace Lipophosphonoxins (LPPOs) represent a new group of membrane-targeting antibiotics. Three generations of LPPOs have been described: First-generation LPPOs, second-generation LPPOs, and LEGO-LPPOs. All three generations have a similar mode of bactericidal action of targeting and disrupting the bacterial cytoplasmic membrane of prokaryotic cells, with limited effect on eukaryotic cells. First-generation LPPOs showed excellent bactericidal activity against Gram-positive species, including multiresistant strains. Second-generation LPPOs broaden the antibiotic effect also against Gram-negative bacteria. However, both first- and second-generation LPPOs lose their antibacterial activity in the presence of serum albumin. LEGO-LPPOs were found to be active against both Gram-positive and Gram-negative bacteria, have better selectivity as compared to first- and second-generation resistance to LEGO-LPPOs was also not observed, and are active even in the presence of serum albumin. Second-generation LPPOs have been studied as antimicrobial additives in bone cement and as nanofiber dressing components in the treatment of wound infections in mice. Second-generation LPPOs and LEGO-LPPOs were also tested to treat ex vivo simulated endodontic infections in dental root canals. The results of all these studies were encouraging and suggested further investigation of LPPOs in these indications. This paper aims to review and compile published data on LPPOs. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2024 Elektronická adresa https://doi.org/10.3390/pharmaceutics15102395
Počet záznamů: 1