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Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation
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SYSNO ASEP 0576684 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation Tvůrce(i) Vydra Boušová, Kristýna (UOCHB-X) ORCID
Zouharová, Monika (UOCHB-X) ORCID
Jirásková, Kateřina (UOCHB-X) ORCID, RID
Vetýšková, Veronika (UOCHB-X) ORCIDČíslo článku 15162 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI - ISSN 1661-6596
Roč. 24, č. 20 (2023)Poč.str. 21 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova TRPM channels ; calmodulin ; calcium homeostasis ; calmodulin binding site ; regulation Obor OECD Biochemistry and molecular biology Způsob publikování Open access Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 001095430100001 EID SCOPUS 85175280181 DOI https://doi.org/10.3390/ijms242015162 Anotace Transient receptor potential melastatin (TRPM) channels, a subfamily of the TRP superfamily, constitute a diverse group of ion channels involved in mediating crucial cellular processes like calcium homeostasis. These channels exhibit complex regulation, and one of the key regulatory mechanisms involves their interaction with calmodulin (CaM), a cytosol ubiquitous calcium-binding protein. The association between TRPM channels and CaM relies on the presence of specific CaM-binding domains in the channel structure. Upon CaM binding, the channel undergoes direct and/or allosteric structural changes and triggers down- or up-stream signaling pathways. According to current knowledge, ion channel members TRPM2, TRPM3, TRPM4, and TRPM6 are directly modulated by CaM, resulting in their activation or inhibition. This review specifically focuses on the interplay between TRPM channels and CaM and summarizes the current known effects of CaM interactions and modulations on TRPM channels in cellular physiology. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2024 Elektronická adresa https://doi.org/10.3390/ijms242015162
Počet záznamů: 1