Počet záznamů: 1
Synthesis and Biological Evaluation of α-Tocopherol Derivatives as Potential Anticancer Agents
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SYSNO ASEP 0575549 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Synthesis and Biological Evaluation of α-Tocopherol Derivatives as Potential Anticancer Agents Tvůrce(i) Baj, A. (PL)
Rárová, L. (CZ)
Ratkiewicz, M. (PL)
Strnad, Miroslav (UEB-Q) RID, ORCID
Witkowski, Z. (PL)Celkový počet autorů 5 Číslo článku 1860 Zdroj.dok. Processes. - : MDPI
Roč. 11, č. 6 (2023)Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova apoptosis ; cancer ; mitocans ; vitamin E derivatives ; α-tocopheryl succinate (α-TS) ; α-tocopheryloxyacetic acid (α-TEA) Obor OECD Chemical engineering (plants, products) Způsob publikování Open access Institucionální podpora UEB-Q - RVO:61389030 UT WOS 001021158200001 EID SCOPUS 85163884587 DOI 10.3390/pr11061860 Anotace α-Tocopheryl succinate (α-TS) and α-tocopheryloxyacetic acid (α-TEA) are potent inducers of apoptosis in cancer cells and efficient suppressors of tumors in experimental model cancer cell lines. They exhibit selective cytotoxicity against tumor cells and very limited or no toxicity toward nonmalignant cells. In the present work, a series of new α-tocopherol derivatives were synthesized as analogs of α-TS and α-TEA. The cytotoxic activity of obtained compounds was tested using three human cancer cell lines, including chronic lymphoblastic leukemia (CEM), breast adenocarcinoma (MCF7), cervical adenocarcinoma (HeLa), and normal human fibroblasts (BJ). The introduction of an alkyl substituent into the ether-linked acetic acid moiety in α-TEA increased anticancer activity. α-Tocopheryloxy-2-methylpropanoic acid with two additional geminal methyl groups was more active against CEM cells compared to α-TEA and non-toxic to normal cells. In order to acquire a deeper understanding of the biological activity of synthesized compounds, a molecular docking study was also conducted. Our research confirmed that vitamin E derivatives are interesting and valuable compounds in terms of their potential therapeutic use as anticancer agents. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2024 Elektronická adresa https://doi.org/10.3390/pr11061860
Počet záznamů: 1