Počet záznamů: 1
Synthesis and self-assembling of hyaluronan grafted with ceramide NP for topical drug delivery
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SYSNO ASEP 0575039 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Synthesis and self-assembling of hyaluronan grafted with ceramide NP for topical drug delivery Tvůrce(i) Juhaščik, M. (CZ)
Štarmanová, K. (CZ)
Brandejsová, M. (CZ)
Večeřová, P. (CZ)
Hermannová, M. (CZ)
Exnerová, A. (CZ)
Vagnerová, H. (CZ)
Štrympl, O. (CZ)
Nešporová, K. (CZ)
Kováčik, A. (CZ)
Velebný, V. (CZ)
Huerta-Ángeles, Gloria (UMCH-V) ORCID, RIDČíslo článku 121283 Zdroj.dok. Carbohydrate Polymers. - : Elsevier - ISSN 0144-8617
Roč. 321, 1 December (2023)Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova ceramides ; hyaluronan ; skin penetration Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 001065166500001 EID SCOPUS 85168762122 DOI 10.1016/j.carbpol.2023.121283 Anotace In this work, amphiphilic hyaluronan was synthesized by grafting succinylated N-oleoyl-phytosphingosine via esters bonds. Succinylated N-oleoyl-phytosphingosine (sCER) was first prepared by esterification of hydroxyl moieties of the ceramide with succinic anhydride. The esterification of hyaluronan was governed by crowding effect. The oligomeric HA-sCER derivatives exhibited a strong self-aggregation as evidenced by a very low critical aggregation concentration (1.9 μg mL−1), higher pyrene binding constant (KB), and the smallest particle size (30 nm) in solution. The self-aggregation properties demonstrated to be a function of the substitution degree and molecular weight of HA. The prepared derivatives were non-cytotoxic towards cell lines NIH-3T3. Nanoparticles prepared using oligomeric HA-sCER derivatives improved the penetration of Nile red dye through the stratum corneum due to their smaller size (≤50 nm). The fluorescence intensity localized at the stratum corneum was higher for oligomeric HA-sCER. A significant inhibition of the pro-inflammatory cytokine interleukin-6 production was observed in vitro in macrophages differentiated from THP-1 cells. These findings showed that HA-sCER constituted a promising active ingredient for cosmetics use. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2024 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0144861723007488?via%3Dihub
Počet záznamů: 1