Počet záznamů: 1
Plasmatic apelin shows a promising potential as a screening biomarker for atrial fibrillation
- 1.
SYSNO ASEP 0573133 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Plasmatic apelin shows a promising potential as a screening biomarker for atrial fibrillation Tvůrce(i) Bezák, B. (SK)
Snopek, P. (SK)
Tóthová, L. (SK)
Jajcay, Nikola (UIVT-O) RID, ORCID, SAI
Mojto, V. (SK)
Farský, Š. (SK)
Gmitterová, K. (SK)
Krivošík, M. (SK)
Stanková, S. (SK)
Duraníková, O. (SK)
Kollárová, M. (SK)
Petríková, K. (SK)
Böhm, A. (SK)Zdroj.dok. Bratislavske Lekarske Listy. - : AEPress - ISSN 0006-9248
Roč. 124, č. 5 (2023), s. 368-372Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. SK - Slovensko Klíč. slova biomarker ; apelin ; arrhythmia ; atrial fibrillation Obor OECD Cardiac and Cardiovascular systems Způsob publikování Open access Institucionální podpora UIVT-O - RVO:67985807 UT WOS 000978786500006 EID SCOPUS 85152244416 DOI https://doi.org/10.4149/BLL_2023_056 Anotace OBJECTIVES: Purpose of this study was to evaluate properties of apelin, a peptide detectable in peripheral blood, for atrial fibrillation (AF) detection in a diverse population of patients covering a broad spectrum from healthy to polymorbid patients. BACKGROUND: AF is the most common cardiac arrhythmia with constantly increasing incidence and prevalence. Currently available diagnostic tools do not provide sufficient detection rate. Large proportion of patients with AF remains undiagnosed and the possibility of screening at-risk groups would be significantly beneficial. METHODS: We designed this study as a multi-centre retrospective study. Study population included 183 patients. 64 in non-AF and 119 in AF group. RESULTS: Apelin plasma concentration was significantly lower in AF group compared to non-AF group (p < 0.001). Receiver operating characteristic analysis of apelin as a predictor of AF scored area under the curve of 0.79, sensitivity = 0.941 and specificity = 0.578. Multivariate analysis using logistic regression adjusted for age, BMI, apelin, dilated LV, dilated LA, arterial hypertension, and gender showed only apelin and age to be statistically significant contributors for AF. CONCLUSION: Apelin might be a promising biomarker for detecting AF in our study population. These results suggest promising potential of apelin as a screening biomarker for AF (Tab. 2, Fig. 1, Ref. 46). Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2024 Elektronická adresa https://dx.doi.org/10.4149/BLL_2023_056
Počet záznamů: 1