Počet záznamů: 1  

Dysregulation of hypoxia-inducible factor 1 alpha in the sympathetic nervous system accelerates diabetic cardiomyopathy

  1. 1.
    SYSNO ASEP0571541
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevDysregulation of hypoxia-inducible factor 1 alpha in the sympathetic nervous system accelerates diabetic cardiomyopathy
    Tvůrce(i) Hrabalová, Petra (BTO-N) RID
    Bohuslavová, Romana (BTO-N) RID
    Matějková, Kateřina (BTO-N)
    Papoušek, František (FGU-C)
    Sedmera, David (FGU-C) RID, ORCID, SAI
    Abaffy, Pavel (BTO-N)
    Kolář, František (FGU-C) RID, ORCID, SAI
    Pavlínková, Gabriela (BTO-N) RID, ORCID
    Celkový počet autorů8
    Číslo článku88
    Zdroj.dok.Cardiovascular Diabetology. - : BioMed Central
    Roč. 22, č. 1 (2023)
    Poč.str.21 s.
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovaCardiac function ; Inflammation ; Diabetic cardiomyopathy ; Collagen deposition ; Sympathetic neurons
    Vědní obor RIVFB - Endokrinologie, diabetologie, metabolizmus, výživa
    Obor OECDEndocrinology and metabolism (including diabetes, hormones)
    CEPLX22NPO5104 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
    GA21-03847S GA ČR - Grantová agentura ČR
    EF18_046/0016045 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
    Výzkumná infrastrukturaCCP II - 90126 - Ústav molekulární genetiky AV ČR, v. v. i.
    Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i.
    Způsob publikováníOpen access
    Institucionální podporaBTO-N - RVO:86652036 ; FGU-C - RVO:67985823
    UT WOS000971837600002
    EID SCOPUS85152863980
    DOI10.1186/s12933-023-01824-5
    AnotaceBackgroundAn altered sympathetic nervous system is implicated in many cardiac pathologies, ranging from sudden infant death syndrome to common diseases of adulthood such as hypertension, myocardial ischemia, cardiac arrhythmias, myocardial infarction, and heart failure. Although the mechanisms responsible for disruption of this well-organized system are the subject of intensive investigations, the exact processes controlling the cardiac sympathetic nervous system are still not fully understood. A conditional knockout of the Hif1a gene was reported to affect the development of sympathetic ganglia and sympathetic innervation of the heart. This study characterized how the combination of HIF-1 alpha deficiency and streptozotocin (STZ)-induced diabetes affects the cardiac sympathetic nervous system and heart function of adult animals.MethodsMolecular characteristics of Hif1a deficient sympathetic neurons were identified by RNA sequencing. Diabetes was induced in Hif1a knockout and control mice by low doses of STZ treatment. Heart function was assessed by echocardiography. Mechanisms involved in adverse structural remodeling of the myocardium, i.e. advanced glycation end products, fibrosis, cell death, and inflammation, was assessed by immunohistological analyses.ResultsWe demonstrated that the deletion of Hif1a alters the transcriptome of sympathetic neurons, and that diabetic mice with the Hif1a-deficient sympathetic system have significant systolic dysfunction, worsened cardiac sympathetic innervation, and structural remodeling of the myocardium.ConclusionsWe provide evidence that the combination of diabetes and the Hif1a deficient sympathetic nervous system results in compromised cardiac performance and accelerated adverse myocardial remodeling, associated with the progression of diabetic cardiomyopathy.
    PracovištěBiotechnologický ústav
    KontaktMonika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700
    Rok sběru2024
    Elektronická adresahttps://cardiab.biomedcentral.com/articles/10.1186/s12933-023-01824-5
Počet záznamů: 1  

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