Počet záznamů: 1
Astrocytic TRPV4 Channels and Their Role in Brain Ischemia
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SYSNO ASEP 0571198 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Astrocytic TRPV4 Channels and Their Role in Brain Ischemia Tvůrce(i) Turečková, Jana (UEM-P) ORCID
Heřmanová, Zuzana (UEM-P) ORCID
Marchetti, Valeria (UEM-P)
Anděrová, Miroslava (UEM-P) RID, ORCIDČíslo článku 7101 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI - ISSN 1661-6596
Roč. 24, č. 8 (2023)Poč.str. 22 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova TRPV4 ; Ca2+ signaling ; ischemia ; glia ; astrocytes Obor OECD Neurosciences (including psychophysiology CEP LX22NPO5107 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA20-05770S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 000977769800001 EID SCOPUS 85156151784 DOI https://doi.org/10.3390/ijms24087101 Anotace Transient receptor potential cation channels subfamily V member 4 (TRPV4) are non-selective cation channels expressed in different cell types of the central nervous system. These channels can be activated by diverse physical and chemical stimuli, including heat and mechanical stress. In astrocytes, they are involved in the modulation of neuronal excitability, control of blood flow, and brain edema formation. All these processes are significantly impaired in cerebral ischemia due to insufficient blood supply to the tissue, resulting in energy depletion, ionic disbalance, and excitotoxicity. The polymodal cation channel TRPV4, which mediates Ca2+ influx into the cell because of activation by various stimuli, is one of the potential therapeutic targets in the treatment of cerebral ischemia. However, its expression and function vary significantly between brain cell types, and therefore, the effect of its modulation in healthy tissue and pathology needs to be carefully studied and evaluated. In this review, we provide a summary of available information on TRPV4 channels and their expression in healthy and injured neural cells, with a particular focus on their role in ischemic brain injury. Pracoviště Ústav experimentální medicíny Kontakt Arzuv Čaryjeva, arzuv.caryjeva@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2024 Elektronická adresa https://www.mdpi.com/1422-0067/24/8/7101
Počet záznamů: 1