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Pre-clinical evidence that methylphenidate increases motivation and/or reward preference to search for high value rewards
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SYSNO ASEP 0570433 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Pre-clinical evidence that methylphenidate increases motivation and/or reward preference to search for high value rewards Tvůrce(i) Pulido, L. N. (BR)
Pochapski, J. A. (BR)
Sugi, A. (BR)
Esaki, J. Y. (BR)
Stresser, J. L. (BR)
Sanchez, W. N. (BR)
Baltazar, G. (BR)
Levčík, David (FGU-C) RID, ORCID
Fuentes, R. (CL)
Da Cunha, C. (BR)Číslo článku 114065 Zdroj.dok. Behavioural Brain Research. - : Elsevier - ISSN 0166-4328
Roč. 437, 2 February (2023)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Methylphenidate ; spatial memory ; motivation ; incentive salience ; dopamine ; attention deficit hyperactivity disorder Obor OECD Neurosciences (including psychophysiology CEP NU20-04-00147 GA MZd - Ministerstvo zdravotnictví Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000862723900007 EID SCOPUS 85138020181 DOI https://doi.org/10.1016/j.bbr.2022.114065 Anotace Methylphenidate is a stimulant used to treat attention deficit and hyperactivity disorder (ADHD). In the last decade, illicit use of methylphenidate has increased among healthy young adults, who consume the drug under the assumption that it will improve cognitive performance. However, the studies that aimed to assess the methylphenidate effects on memory are not consistent. Here, we tested whether the effect of methylphenidate on a spatial memory task can be explained as a motivational and/or a reward effect. We tested the effects of acute and chronic i.p. administration of 0.3, 1 or 3 mg/kg of methylphenidate on motivation, learning and memory by using the 8-arm radial maze task. Adult male Wistar rats learned that 3 of the 8 arms of the maze were consistently baited with 1, 3, or 6 sucrose pellets, and the number of entries and reentries into reinforced and non-reinforced arms of the maze were scored. Neither acute nor chronic (20 days) methylphenidate treatment affected the number of entries in the non-baited arms. However, chronic, but not acute, 1–3 mg/kg methylphenidate increased the number of reentries in the higher reward arms, which suggests a motivational/rewarding effect rather than a working memory deficit. In agreement with this hypothesis, the methylphenidate treatment also decreased the approach latency to the higher reward arms, increased the approach latency to the low reward arm, and increased the time spent in the high, but not low, reward arm. These findings suggest that methylphenidate may act more as a motivational enhancer rather than a cognitive enhancer in healthy people. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2024 Elektronická adresa https://doi.org/10.1016/j.bbr.2022.114065
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