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Surface effect of iron oxide nanoparticles on the suppression of oxidative burst in cells
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SYSNO ASEP 0569400 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Surface effect of iron oxide nanoparticles on the suppression of oxidative burst in cells Tvůrce(i) Swietek, Malgorzata Anna (UMCH-V) RID, ORCID
Gunár, Kristýna (UMCH-V) RID, ORCID
Kolodziej, A. (PL)
Weselucha-Birczynska, A. (PL)
Veverka, Pavel (FZU-D) RID, ORCID
Šebestová Janoušková, Olga (UMCH-V) RID
Horák, Daniel (UMCH-V) RID, ORCIDZdroj.dok. Journal of Cluster Science - ISSN 1040-7278
Roč. 34, č. 1 (2023), s. 323-334Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova oxidative stress ; magnetic nanoparticles ; immune cells Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Vědní obor RIV – spolupráce Fyzikální ústav - Fyzika pevných látek a magnetismus CEP GC20-02177J GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 ; FZU-D - RVO:68378271 UT WOS 000746347000002 EID SCOPUS 85123491079 DOI 10.1007/s10876-022-02222-9 Anotace Overproduction of reactive oxygen species (ROS) is an unwanted phenomenon, leading to cellular damages. The aim of this study was to investigate the ability of neat and surface-modified iron oxide nanoparticles (IONs) to eliminate ROS produced by immune cells. The employed coating included heparin (ION@Hep) or heparin and chitosan grafted with phenolic compounds famous for antioxidant properties, i.e., gallic acid (ION@Ch-G) or phloroglucinol (ION@CH-P). A total peroxyl radical-trapping potential assay showed that both types of the phenolic compounds-modified IONs exhibited superior radical scavenging activity over the neat and ION@Hep particles at 100 μg/mL. Up to ~ 75 μg/mL, the particles were non-toxic towards RAW 264.7 macrophages. Capability of the particles to limit ROS production was investigated in vitro on polymorphonuclear (PMN) cells isolated from human whole blood and expressed as an ability to reduce the oxidative burst in the stimulated cells, as well as a potential to increase the viability of bacteria cultivated with the PMN cells. The highest viability of bacteria was observed for the neat and ION@Ch-G, while the ION@Ch-G particles also the most effectively inhibited the oxidative burst. The results indicated that ROS scavenging depend on the presence of polymer and selection of phenols, enriching the IONs. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2024 Elektronická adresa https://link.springer.com/article/10.1007/s10876-022-02222-9
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