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Utility of quantitative MRI metrics in human brain ageing research
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SYSNO ASEP 0568186 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Utility of quantitative MRI metrics in human brain ageing research Tvůrce(i) Filip, P. (CZ)
Kokošová, V. (CZ)
Valenta, Zdeněk (UIVT-O) RID, SAI, ORCID
Baláž, M. (CZ)
Mangia, S. (US)
Michaeli, S. (US)
Vojtíšek, L. (CZ)Číslo článku 1099499 Zdroj.dok. Frontiers in Aging Neuroscience. - : Frontiers Media - ISSN 1663-4365
Roč. 15, March (2023)Poč.str. 10 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova ageing ; quantitative MRI ; rotating frame relaxometry ; diffusion weighted imaging ; resting state functional MRI Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Clinical neurology CEP LM2018129 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UIVT-O - RVO:67985807 UT WOS 000954641900001 EID SCOPUS 85150736986 DOI https://doi.org/10.3389/fnagi.2023.1099499 Anotace The advent of new, advanced quantitative MRI metrics allows for in vivo evaluation of multiple biological processes highly relevant for ageing. The presented study combines several MRI parameters hypothesised to detect distinct biological characteristics as myelin density, cellularity, cellular membrane integrity and iron concentration. 116 healthy volunteers, continuously distributed over the whole adult age span, underwent a multi-modal MRI protocol acquisition. Scatterplots of individual MRI metrics revealed that certain MRI protocols offer much higher sensitivity to early adulthood changes while plateauing in higher age (e.g. global functional connectivity in cerebral cortex or orientation dispersion index in white matter), while other MRI metrics provided reverse ability – stable levels in young adulthood with sharp changes with rising age (e.g. T1ρ and T2ρ). Nonetheless, despite the previously published validations of specificity towards microstructural biology based on cytoarchitectonic maps in healthy population or alterations in certain pathologies, several metrics previously hypothesised to be selective to common measures failed to show similar scatterplot distributions, pointing to further confounding factors directly related to age. Furthermore, other metrics, previously shown to detect different biological characteristics, exhibited substantial intercorrelations, be it due to the nature of the MRI protocol itself or co-dependence of relevant biological microstructural processes. All in all, the presented study provides a unique basis for the design and choice of relevant MRI parameters depending on the age group of interest. Furthermore, it calls for caution in simplistic biological inferences in ageing based on one simple MRI metric, even though previously validated under other conditions. Complex multi-modal approaches combining several metrics to extract the shared subcomponent will be necessary to achieve the desired goal of histological MRI. Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2024 Elektronická adresa https://doi.org/10.3389/fnagi.2023.1099499
Počet záznamů: 1