Počet záznamů: 1
Photochemistry of (Z)-isovinylneoxanthobilirubic acid methyl ester, a bilirubin dipyrrinone subunit: femtosecond transient absorption and stimulated Raman emission spectroscopy
- 1.0568051 - FZÚ 2023 RIV US eng J - Článek v odborném periodiku
Madea, D. - Mujawar, T. - Dvořák, A. - Pospíšilová, K. - Muchová, L. - Čubáková, Petra - Kloz, M. - Švenda, J. - Vítek, L. - Klán, P.
Photochemistry of (Z)-isovinylneoxanthobilirubic acid methyl ester, a bilirubin dipyrrinone subunit: femtosecond transient absorption and stimulated Raman emission spectroscopy.
Journal of Organic Chemistry. Roč. 87, č. 5 (2022), s. 3089-3103. ISSN 0022-3263. E-ISSN 1520-6904
Grant CEP: GA ČR(CZ) GM21-09692M
Institucionální podpora: RVO:68378271
Klíčová slova: multivariate cure resolution * singlet oxygen * propentdyopents 5-(2-oxo-2h-pyrrol-5-ylmethylene)pyrrol-2(5H)-ones * sensitized photooxygenation
Obor OECD: Particles and field physics
Impakt faktor: 3.6, rok: 2022
Způsob publikování: Omezený přístup
https://doi.org/10.1021/acs.joc.1c02870
Bilirubin (BR) is an essential metabolite formed by the catabolism of heme. Phototherapy with blue-green light can be applied to reduce high concentrations of BR in blood and is used especially in the neonatal period. In this work, we studied the photochemistry of (Z)-isovinylneoxanthobilirubic acid methyl ester, a dipyrrinone subunit of BR, by steady-state absorption, femtosecond transient absorption, and stimulated Raman spectroscopies. Both the (Z)- and (E)-configurational isomers of isovinylneoxanthobilirubic acid undergo wavelength-dependent and reversible photoisomerization. The isomerization from the excited singlet state is ultrafast (the lifetimes of (Z)- and (E)- isomers were found to be ∼0.9 and 0.1 ps, respectively), and its efficiencies increase with increased photon energy. In addition, we studied sensitized photooxidation of the dipyrrinone subunit by singlet oxygen that leads to the formation of propentdyopents.
Trvalý link: https://hdl.handle.net/11104/0339401
Počet záznamů: 1