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Morphology of Anterior Cingulate Cortex and Its Relation to Schizophrenia

  1. 1.
    0566011 - ÚI 2024 RIV CH eng J - Článek v odborném periodiku
    Lahutsina, A. - Španiel, F. - Mrzilková, J. - Morozova, A. - Brabec, Marek - Musil, V. - Zach, P.
    Morphology of Anterior Cingulate Cortex and Its Relation to Schizophrenia.
    Journal of Clinical Medicine. Roč. 12, č. 1 (2023), č. článku 33. E-ISSN 2077-0383
    Grant CEP: GA MŠMT(CZ) EF16_019/0000766
    Institucionální podpora: RVO:67985807
    Klíčová slova: MRI * schizophrenia * morphology * anatomy * cingulate and paracingulate sulci
    Obor OECD: Statistics and probability
    Impakt faktor: 3.9, rok: 2022
    Způsob publikování: Open access
    https://dx.doi.org/10.3390/jcm12010033

    Cortical folding of the anterior cingulate cortex (ACC), particularly the cingulate (CS) and the paracingulate (PCS) sulci, represents a neurodevelopmental marker. Deviations in in utero development in schizophrenia can be traced using CS and PCS morphometry. In the present study, we measured the length of CS, PCS, and their segments on T1 MRI scans in 93 patients with first- episode schizophrenia and 42 healthy controls. Besides the length, the frequency and the left-right asymmetry of CS/PCS were compared in patients and controls. Distribution of the CS and PCS morphotypes in patients was different from controls. Parcellated sulcal pattern CS3a in the left hemisphere was longer in patients (53.8 ± 25.7 mm vs. 32.7 ± 19.4 mm in controls, p < 0.05), while in CS3c it was reversed—longer in controls (52.5 ± 22.5 mm as opposed to 36.2 ± 12.9 mm, n.s. in patients). Non parcellated PCS in the right hemisphere were longer in patients compared to controls (19.4 ± 10.2 mm vs. 12.1 ± 12.4 mm, p < 0.001). Therefore, concurrent presence of PCS1 and CS1 in the left hemisphere and to some extent in the right hemisphere may be suggestive of a higher probability of schizophrenia.
    Trvalý link: https://hdl.handle.net/11104/0337446

     
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