Počet záznamů: 1
Sensing nitriles with THz spectroscopy of urine vapours from cancers patients subject to chemotherapy
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SYSNO ASEP 0564302 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Sensing nitriles with THz spectroscopy of urine vapours from cancers patients subject to chemotherapy Tvůrce(i) Vaks, V. (RU)
Anfertev, V. (RU)
Chernyaeva, M. (RU)
Domracheva, E. (RU)
Yablokov, A. (RU)
Maslennikova, A. (RU)
Zhelesnyak, A. (RU)
Baranov, A. (FR)
Schevchenko, Yuliia (FZU-D)
Pereira, Mauro Fernandes (FZU-D) ORCIDCelkový počet autorů 10 Číslo článku 18117 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 12, č. 1 (2022)Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova superlattice ; THz spectroscopy ; chemotherapy ; detection Vědní obor RIV BM - Fyzika pevných látek a magnetismus Obor OECD Condensed matter physics (including formerly solid state physics, supercond.) Způsob publikování Open access Institucionální podpora FZU-D - RVO:68378271 UT WOS 000876924900100 EID SCOPUS 85140862324 DOI 10.1038/s41598-022-22783-z Anotace A THz nonstationary high-resolution spectrometer based on semiconductor superlattice multipliers is applied to investigate the dynamics of urine composition for cancer patients treated with chemotherapy. The molecular urine composition of healthy volunteers and cancer patients was compared and contrasted. We have found a set of nitriles that either appeared after chemotherapy or increased in content, which are expected as a result of bio-chemical damage to the liver. While no damage can be detected at this stage by existing clinical methods, the identified nitriles are candidates for further large-scale systematic testing towards markers for nephrotoxicity of chemotherapy at an early stage of the treatment, when conventional diagnostics cannot identify substantial organ damage. Comparing the metabolite concentration dynamics with side effects during chemotherapy might then help individuate patients prone to severe complications and correct the treatment. Our devices are game-changers for THz spectroscopy of liquids: they allow spanning four different frequency ranges for a general evaluation of most substances found in the liquid and selecting a spectral interval that bypasses the strong absorption lines from substances such as water and ammonia, which may otherwise mask the detection of the target metabolites. Pracoviště Fyzikální ústav Kontakt Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Rok sběru 2023 Elektronická adresa https://hdl.handle.net/11104/0336442
Počet záznamů: 1