Počet záznamů: 1
Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System
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SYSNO ASEP 0560226 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System Tvůrce(i) Kelbich, P. (CZ)
Hejčl, Aleš (UEM-P) RID, ORCID
Krejsek, J. (CZ)
Radovnický, T. (CZ)
Matuchová, I. (CZ)
Lodin, J. (CZ)
Špička, J. (CZ)
Sameš, M. (CZ)
Procházka, J. (CZ)
Hanuljaková, E. (CZ)
Vachata, P. (CZ)Číslo článku 300 Zdroj.dok. Life. - : MDPI
Roč. 11, č. 4 (2021)Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova CNS haemorrhage ; inflammation in CNS ; cerebrospinal fluid ; total protein in CSF Obor OECD Clinical neurology Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 000643221400001 EID SCOPUS 85104077851 DOI https://doi.org/10.3390/life11040300 Anotace Extravasation of blood in the central nervous system (CNS) represents a very strong damaged associated molecular patterns (DAMP) which is followed by rapid inflammation and can participate in worse outcome of patients. We analyzed cerebrospinal fluid (CSF) from 139 patients after the CNS hemorrhage. We compared 109 survivors (Glasgow Outcome Score (GOS) 5-3) and 30 patients with poor outcomes (GOS 2-1). Statistical evaluations were performed using the Wilcoxon signed-rank test and the Mann-Whitney U test. Almost the same numbers of erythrocytes in both subgroups appeared in days 0-3 (p = 0.927) and a significant increase in patients with GOS 2-1 in days 7-10 after the hemorrhage (p = 0.004) revealed persistence of extravascular blood in the CNS as an adverse factor. We assess 43.3% of patients with GOS 2-1 and only 27.5% of patients with GOS 5-3 with low values of the coefficient of energy balance (KEB < 15.0) in days 0-3 after the hemorrhage as a trend to immediate intensive inflammation in the CNS of patients with poor outcomes. We consider significantly higher concentration of total protein of patients with GOS 2-1 in days 0-3 after hemorrhage (p = 0.008) as the evidence of immediate simultaneously manifested intensive inflammation, swelling of the brain and elevation of intracranial pressure. Pracoviště Ústav experimentální medicíny Kontakt Arzuv Čaryjeva, arzuv.caryjeva@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2023 Elektronická adresa https://www.mdpi.com/2075-1729/11/4/300
Počet záznamů: 1